Morris Syndrome: clinical, genetic, and psychosocial perspectives on androgen insensitivity
DOI:
https://doi.org/10.5281/zenodo.13374335Keywords:
Androgen Insensitivity Syndrome, Treatment, GynecologyAbstract
Morris syndrome, or androgen insensitivity syndrome, is a rare genetic condition resulting from impaired response to male sex hormones due to mutations in the AR gene, which encodes the androgen receptor. Individuals with this syndrome have an XY karyotype but exhibit female physical characteristics due to inadequate response to testosterone during fetal development. Clinical presentation can vary, with some patients being diagnosed at different life stages, from childhood to adulthood. Management of the syndrome involves a multidisciplinary approach, including the correction of anatomical anomalies, hormone therapy, and psychological support. The emotional and social implications for patients and their families are significant, highlighting the importance of comprehensive and personalized care. Advances in genetic and therapeutic knowledge continue to improve the quality of life for affected individuals.
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