Intestinal Dysbiosis in Irritable Bowel Syndrome: exploring nutritional approaches as therapeutic strategies
DOI:
https://doi.org/10.5281/zenodo.14923164Keywords:
Irritable Bowel Syndrome, Intestinal Dysbiosis, Nutritional InterventionAbstract
Introduction: In recent years, the relationship between the gut microbiota and Irritable Bowel Syndrome (IBS) has been extensively studied. Scientific evidence suggests that intestinal dysbiosis, characterized by an imbalance in the diversity and abundance of gut microorganisms, factor in the pathophysiology of IBS.The aim of this article is to review the recent literature on the impact of intestinal dysbiosis on Irritable Bowel Syndrome, with an emphasis on evidence-based therapeutic approaches. Methodology: The current study was a narrative review of the qualitative literature on the impact of intestinal dysbiosis on Irritable Bowel Syndrome. This type of review was chosen due to its ability to comprehensively address the issue at hand, allowing for an in-depth theoretical and contextual discussion. Results: Studies show that reducing foods rich in FODMAPs significantly improves IBS symptoms, particularly in patients with intestinal dysbiosis. This protocol involves the temporary reduction or elimination of foods high in FODMAPs to improve symptoms associated with IBS. Furthermore, supplementation with soluble fibers, such as psyllium, helps to alleviate constipation in IBS by increasing the frequency of bowel movements and improving stool consistency. Conclusion: The combination of nutritional and pharmacological interventions has shown promising results, but longitudinal studies are needed to deepen the understanding of the causality between dysbiosis and IBS symptoms, as well as to determine the durability of these interventions.
References
BARRETT, E. et al. Gut microbiota and health: connecting the dots. Frontiers in Cellular and Infection Microbiology, v. 4, p. 204, 2014.
CAMILLERI, M. et al. Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterology & Motility, v. 24, n. 6, p. 503-512, 2012.
CHEY, W. D. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. The American Journal of Gastroenterology, v. 107, n. 11, p. 1702-1712, 2012.
CRYAN, J. F.; DINAN, T. G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, v. 13, n. 10, p. 701-712, 2012.
HALMOS, E. P. et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology, v. 146, n. 1, p. 67-75, 2014.
GOULART ROMUALDO FILHO, A.; ALVES CONTÃO, L.; WILSON GOMES DE SOUZA, A.; RODRIGUES DA SILVA NEUMANN, K. DISBIOSE INTESTINAL: Uma Abordagem
Nutricional. Revista Multidisciplinar do Nordeste Mineiro, [S. l.], v. 12, n. 2, 2024. DOI: 10.61164/rmnm.v12i2.2612.Disponívelem:https://revista.unipacto.com.br/index.php/multidisciplina r/article/view/2612. Acesso em: 21 fev. 2025.
MAYER, E. A. Gut/brain axis and the microbiota. The Journal of Clinical Investigation, v. 125, n. 3, p. 926-938, 2015.
PASSOS M DO CF, MORAES-FILHO JP. Microbiota intestinal nas doenças digestivas. Arq Gastroenterol. 2017;54(3):255–62.
PIMENTEL, M. et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. New England Journal of Medicine, v. 364, n. 1, p. 22-32, 2011.
SANTANA, Renata dos Santoset al. Disbiose intestinal e uso de prebióticos e probióticos comopromotores da saúde humana. Revista Higei@,v. 2, n.3, s.p., 2018. Disponível em: https://periodicos.unimesvirtual.com.br/index.php/higeia/article/download/955/797. Acesso em: 21 fev. 2025.
SILVA, M. T., LEITE, F. M. M., SANTIAGO, F. V. P., DE ALBUQUERQUE, Í. G. S., BRITO, A. P. S. O., & GARCIA, H. C. R. (2020). Diagnóstico e tratamento da síndrome do intestino irritável: revisão sistemática. Pará Research Medical Journal, 4, 0-0.
SIMON, E.; CĂLINOIU, L. F.; MITREA, L.; VODNAR, D. C. Probiotics, prebiotics, and synbiotics: implications and beneficial effects against irritable bowel syndrome. Nutrients, v. 13,
n. 6, p. 2112, 20 jun. 2021. DOI: 10.3390/nu13062112. Disponível em:
https://doi.org/10.3390/nu13062112. Acesso em: 25 jan. 2025.
SIMREN M, PALSSON OS, WHITEHEAD WE. Update on Rome IV Criteria for Colorectal Disorders: Implications for Clinical Practice. Curr Gastroenterol Rep. 2017 Apr;19(4):15. doi: 10.1007/s11894-017-0554-0. PMID: 28374308; PMCID: PMC5378729
VENEGAS, D. P. et al. Short-chain fatty acids: key regulators of the interface between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research, v. 60, n. 4, p. 533-548, 2019.
WIĘCEK, M., PANUFNIK, P., KANIEWSKA, M., LEWANDOWSKI, K., & RYDZEWSKA, G.
(2022). Low-FODMAP Diet for the Management of Irritable Bowel Syndrome in Remission of IBD. Nutrients, 14(21), 4562
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