Cambios en leptina y adiponectina en pacientes con obesidad y sus implicaciones clínicas

Autores/as

DOI:

https://doi.org/10.5281/zenodo.14888355

Palabras clave:

Adiponectina, Leptina, Obesidad, Terapéutica

Resumen

La obesidad es una condición metabólica compleja, asociada con cambios en la secreción de adipocinas, incluidas la leptina y la adiponectina, que desempeñan funciones fundamentales en la regulación de la homeostasis energética y la inflamación. Este estudio tuvo como objetivo analizar los cambios en los niveles de estas adipocinas en pacientes con obesidad y sus implicaciones clínicas. Para ello, se realizó una revisión integradora de la literatura en bases de datos científicas, seleccionando artículos publicados entre 2020 y 2025. Los resultados indicaron que la obesidad se asocia con un aumento de la leptina circulante y una reducción de la adiponectina, contribuyendo a la resistencia a la leptina, a la inflamación crónica y a un mayor riesgo de enfermedades metabólicas, como diabetes mellitus tipo 2 y dislipidemia. Además, se ha demostrado que la relación leptina/adiponectina es un biomarcador prometedor en la evaluación del riesgo cardiometabólico. Las intervenciones basadas en modificaciones del estilo de vida, incluidas dietas equilibradas y actividad física, han demostrado ser eficaces para normalizar estas hormonas. También se han explorado estrategias farmacológicas, como el uso de sensibilizadores de insulina e inhibidores de mediadores inflamatorios, como posibles enfoques terapéuticos. Se concluye que comprender el papel de las adipocinas en la obesidad es fundamental para el desarrollo de estrategias terapéuticas más efectivas, contribuyendo a la reducción de las complicaciones metabólicas asociadas a esta condición.

Biografía del autor/a

  • Fabiana Fonseca Pereira, Centro Universitário ETEP

    Nutricionista

  • Juliana de Fatima da Conceição Veríssimo Lopes, Universidade Federal do Estado do Rio de Janeiro (UNIRIO)

    Nutricionista

  • Rebecca Nascimento da Silveira Gomes, Universidade Federal do Estado do Rio de Janeiro (UNIRIO)

    Graduanda em Enfermagem

  • Georgette Torres Tartari, Universidade Federal do Estado do Rio de Janeiro (UNIRIO)

    Graduanda em Nutrição

  • Anderson Alves da Silva, Universidade Salgado de Oliveira (UNIVERSO)

    Mestre em Ciências da Atividade Física

  • Cristiane Lira Santana, Escola Superior de Ciências da Saúde (ESCS)

    Técnica em Enfermagem Pós-graduada em Gerontologia

  • Juliana Alves Michieletto da Silva, Universidade Unigranrio Afya (UNIGRANRIO)

    Graduanda em Medicina

  • Fabrício Gomes dos Santos, Centro Universitário SENAC/SP

    Nutricionista Pós-graduado em Nutrição Clínica: do Home Care ao Hospital

  • Juliana Moreno Martineli, Universidade Estácio de Sá (UNESA)

    Graduanda em Nutrição

  • Clarice Gaspar da Costa, Centro Universitário Ítalo Brasileiro (UniÍtalo)

    Nutricionista Especialista em Nutrição Humana

Referencias

BLÜHER, M. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology, [s. l.], v. 15, p. 288-298, 2019. DOI: 10.1038/s41574-019-0176-8.

CASTELA, I. et al. Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity. American Journal of Physiology, Endocrinology and Metabolism, [s. l.], v. 324, p. E115-E119, 2023. DOI: 10.1152/ajpendo.00273.2022.

COJOCARU, K. A. et al. Mitochondrial Dysfunction, Oxidative Stress, and Therapeutic Strategies in Diabetes, Obesity, and Cardiovascular Disease. Antioxidants, [s. l.], v. 12, n. 3, p. 658, 2023. DOI: 10.3390/antiox12030658.

CRUCIANI, S. et al. Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment. International Journal of Molecular Sciences, [s. l.], v. 24, n. 3, p. 2310, 2023. DOI: 10.3390/ijms24032310.

DANTAS, H. L. L. et al. Como elaborar uma revisão integrativa: sistematização do método científico. Revista Científica de Enfermagem, São Paulo, v. 12, n. 37, p. 334-345, 2021. DOI: 10.24276/rrecien2022.12.37.334-345.

DESSIE, G. et al. Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, [s. l.], v. 14, p. 3307-3322, 2021. DOI: 10.2147/DMSO.S321311.

DLUDLA, P. V. et al. Adipokines as a therapeutic target by metformin to improve metabolic function: A systematic review of randomized controlled trials. Pharmacological Research, [s. l.], v. 163, p. 105219, 2021. DOI: 10.1016/j.phrs.2020.105219.

FRIEDMAN, J. M. Leptin and the endocrine control of energy balance. Nature Metabolism, [s. l.], v. 1, p. 754-764, 2019. DOI: 10.1038/s42255-019-0095-y.

FRÜHBECK, G. et al. Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte, [s. l.], v. 7, n. 1, p. 57 - 62, 2018. DOI: 10.1080/21623945.2017.1402151.

JIANG, Z. et al. The Adiponectin-SIRT1-AMPK Pathway in Alcoholic Fatty Liver Disease in the Rat. Alcoholism: Clinical and Experimental Research, [s. l.], v. 39, n. 3, p. 424-433, 2015. DOI: 10.1111/acer.12641.

KAZEMINASAB, F. et al. Effects of plant-based diets combined with exercise training on leptin and adiponectin levels in adults with or without chronic diseases: a systematic review and meta-analysis of clinical studies. Frontiers in Nutrition, [s. l.], v. 11, n. 1465378, 2024. DOI: 10.3389/fnut.2024.1465378.

KORAC, A. et al. Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles. Archives of Medical Science, [s. l.], v. 17, n. 2, p. 323-336, 2021. DOI: 10.5114/aoms/92118.

KOTAL, S. et al. A Review on Role of Different Adipokines in Gestational Diabetes. Journal of Advanced Zoology, [s. l.], v. 44, n. S6, p. 2109-2113, 2023. DOI: 10.17762/jaz.v44iS6.2794.

KWON, O.; KIM, K. W.; KIM, M. S. Leptin signalling pathways in hypothalamic neurons. Cellular and Molecular Life Sciences, [s. l.], v. 73, p. 1457-1477, 2016. DOI: 10.1007/s00018-016-2133-1.

LA PAZ, S. M. et al. Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications. The Journal of Nutritional Biochemistry, [s. l.], v. 89, p. 108561, 2021. DOI: 10.1016/j.jnutbio.2020.108561.

LEDERER, A. K. et al. Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants. International Journal of Environmental Research and Public Health, [s. l.], v. 19, n. 11370, p. 1-14, 2022. DOI: 10.3390/ijerph191811370.

LIU, W. et al. Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus: A population-based study. Medicine, Baltimore, v. 99, n. 6, p. e19052, 2020. DOI: 10.1097/MD.0000000000019052.

LONGO, M. et al. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. International Journal of Molecular Sciences, [s. l.], v. 20, n. 9, p. 2358, 2019. DOI: 10.3390/ijms20092358.

MAYERHOFER, E. et al. A Multidisciplinary Intervention in Childhood Obesity Acutely Improves Insulin Resistance and Inflammatory Markers Independent From Body Composition. Frontiers in Pediatrics, [s. l.], v. 8, p. 52, 2020. DOI: 10.3389/fped.2020.00052.

MILLAR, S. R.; PERRY, I. J.; PHILLIPS, C. M. Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation. European Journal of Clinical Investigation, [s. l.], v. 54, n. 2, p. e14104, 2023. DOI: 10.1111/eci.14104.

MILLER, E. S. et al. Chronic stress induces persistent low-grade inflammation. American Journal of Surgery, [s. l.], v. 218, n. 4, p. 677-683, 2019. DOI: 10.1016/j.amjsurg.2019.07.006.

MIR, M. M. et al. Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study. Journal of Personalized Medicine, [s. l.], v. 12, n. 735, p. 1-16, 2022. DOI: 10.3390/jpm12050735.

NAMBI, G. et al. Clinical (BMI and MRI) and Biochemical (Adiponectin, Leptin, TNF-α, and IL-6) Effects of High-Intensity Aerobic Training with High-Protein Diet in Children with Obesity Following COVID-19 Infection. International Journal of Molecular Sciences, [s. l.], v. 19, n. 7194, p. 1-12, 2022. DOI: 10.3390/ijerph19127194.

OBRADOVIC, M. et al. Leptin and Obesity: Role and Clinical Implication. Frontiers in Endocrinology, [s. l.], v. 12, n. 585887, 2021. DOI: 10.3389/fendo.2021.585887.

RAFEY, M. F. et al. Changes in the Leptin to Adiponectin Ratio Are Proportional to Weight Loss After Meal Replacement in Adults With Severe Obesity. Frontiers in Nutrition, [s. l.], v. 9, n. 845574, 2022. DOI: 10.3389/fnut.2022.845574.

RAJESH, Y.; SARKAR, D. Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer. International Journal of Molecular Sciences, [s. l.], v. 22, n. 2163, p. 1-28, 2021. DOI: 10.3390/ijms22042163.

RECINELLA, L. et al. Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases. Frontiers in Physiology, [s. l.], v. 11, 2020. DOI: 10.3389/fphys.2020.578966.

REJEKI, P. S. et al. The Positive Effect of Four-Week Combined Aerobic-Resistance Training on Body Composition and Adipokine Levels in Obese Females. Sports, Basel, v. 11, n. 4, p. 90, 2023. DOI: 10.3390/sports11040090.

REN, Y. et al. Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation. Frontiers in Endocrinology, [s. l.], v. 13, n. 873699, p. 1-26, 2022. DOI: 10.3389/fendo.2022.873699.

RIZZO, M., FASANO, R., & PAOLISSO, G. Adiponectin and Cognitive Decline. International Journal of Molecular Sciences, [s. l.], v. 21, n. 6, p. 2010, 2020. DOI: 10.3390/ijms21062010.

SAHIN-EFE, A. et al. Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study. Metabolism, [s. l.], v. 79, p. 24-32, 2018. DOI: 10.1016/j.metabol.2017.10.011.

SENKUS, K. E. et al. Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention. Nutrition & Diabetes, [s. l.], v. 12, n. 30, p. 1-7, 2022. DOI:10.1038/s41387-022-00207-1.

SHAMS, H. A.; AZIZ, H. M.; AL-KURAISHY, H. M. The potential effects of metformin and/or sitagliptin on leptin/adiponectin ratio in diabetic obese patients: a new therapeutic effect. The Journal of the Pakistan Medical Association, [s. l.], v. 74, n. 10, Suppl. 8, p. S241-S245, 2024. DOI: 10.47391/JPMA-BAGH-16-54.

STEIN, R.; FERRARI, F.; SCOLARI, F. Genetics, Dyslipidemia, and Cardiovascular Disease: New Insights. Current Cardiology Reports, [s. l.], v. 21, n. 68, p. 1-12, 2019. DOI: 10.1007/s11886-019-1161-5.

STRAUB, L. G.; SCHERER, P. E. Metabolic Messengers: adiponectin. Nature Metabolism, [s. l.], v. 1, p. 334-339, 2019. DOI: 10.1038/s42255-019-0041-z.

WU, P. et al. Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Effect of SGLT2 Inhibitor on Blood Leptin and Adiponectin Level in Patients with Type 2 Diabetes. Hormone and Metabolic Research, [s. l.], v. 51, n. 8, p. 487-494, 2019. DOI: 10.1055/a-0958-2441.

WUEEST, S. et al. IL-6 Receptor Blockade Increases Circulating Adiponectin Levels in People with Obesity: An Explanatory Analysis. Metabolites, [s. l.], v. 11, n. 79, p. 1-7, 2021. DOI: 10.3390/metabo11020079.

WÜRFEL, M. et al. Adipokines as Clinically Relevant Therapeutic Targets in Obesity. Biomedicines, [s. l.], v. 11, n. 1427, p. 1-26, 2023. DOI: 10.3390/biomedicines11051427.

ZHAO, Q. Y. et al. Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models. Zoological Research, [s. l.], v. 41, n. 5, p. 539-551, 2020. DOI: 10.24272/j.issn.2095-8137.2020.051.

ZHAO, S.; KUSMINSKI, C. M.; SCHERER, P. E. Adiponectin, Leptin and Cardiovascular Disorders. Circulation Research, [s. l.], v. 128, n. 1, p. 136-149, 2021. DOI: 10.1161/CIRCRESAHA.120.314458.

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Publicado

2025-02-18

Número

Vol. 2 Núm. 2 (2025)

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Artigos

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Derechos de autor 2025 Journal of Social Issues and Health Sciences (JSIHS)

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Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Cómo citar

PEREIRA, Fabiana Fonseca et al. Cambios en leptina y adiponectina en pacientes con obesidad y sus implicaciones clínicas. Journal of Social Issues and Health Sciences (JSIHS), [S. l.], v. 2, n. 2, 2025. DOI: 10.5281/zenodo.14888355. Disponível em: https://ojs.thesiseditora.com.br/index.php/jsihs/article/view/322.. Acesso em: 22 feb. 2025.