The use of selective serotonin reuptake inhibitors in the treatment of major depression: a bibliographical review

Authors

  • Guilherme Tadeu Souza Batista Author
  • Cinthya Millene do Nascimento Gavilanes Author
  • Gabriel Alejandro do Nascimento Gavilanes Author
  • Jonkelion Dourado Nunes Filho Author
  • Lívia Versiane Oliveira Author

DOI:

https://doi.org/10.5281/zenodo.18143315

Keywords:

Selective Serotonin Reuptake Inhibitors, Treatment, Depressive Disorder Major

Abstract

This article aims to review the existing literature on the use of selective serotonin reuptake inhibitors in the treatment of major depression. Major depression is a prevalent and debilitating psychiatric disorder characterized by persistent feelings of sadness, loss of interest in peaceful activities, changes in appetite and lack of sleep, and difficulty concentrating. Treatments for major depression include psychotherapeutic and pharmacological interventions, such as selective serotonin reuptake inhibitors (SSRIs), which have been highlighted as one of the first lines of treatment due to their efficacy and relatively favorable safety profile. SSRIs work by increasing the availability of serotonin in the brain, a neurotransmitter that plays a crucial role in regulating mood, anxiety and behavior. The literature review provides a detailed look at the efficacy, safety, and side effect profile of these medications, as well as practical considerations and future innovations in the field.

References

AHMADIMANESH, Mahnaz et al. Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression. Journal of Psychopharmacology, v. 33, n. 11, p. 1364-1376, 2019.

ALIPOUR-KIVI, Arman et al. The effect of drug holidays on sexual dysfunction in men treated with selective serotonin reuptake inhibitors (SSRIs) other than fluoxetine: an 8-week open-label randomized clinical trial. BMC psychiatry, v. 24, n. 1, p. 67, 2024.

DEMARCHI, Mariana Eduarda et al. Inibidores seletivos de recaptação de serotonina no tratamento da depressão: síndrome de descontinuação e/ou de dependência?. Research, Society and Development, v. 9, n. 9, p. e815998035-e815998035, 2020.

GONÇALVES, Maria Jaildes Melquiades et al. Inibidores seletivos da recaptação de serotonina: uma opção segura no tratamento da depressão em idosos. Referências em Saúde do Centro Universitário Estácio de Goiás, v. 2, n. 01, p. 126-134, 2019.

GRYGLEWSKI, Gregor et al. Modeling the acute pharmacological response to selective serotonin reuptake inhibitors in human brain using simultaneous PET/MR imaging. European Neuropsychopharmacology, v. 29, n. 6, p. 711-719, 2019.

LEWIS, Gemma et al. Maintenance or discontinuation of antidepressants in primary care. New England Journal of Medicine, v. 385, n. 14, p. 1257-1267, 2021.

LUZ, Poliana Barboza; RAMOS, Sirlei; GEISLER, Sandonaid Andrei. Efeitos adversos do uso de antidepressivos por estudantes da área da saúde. Revista JRG de Estudos Acadêmicos, v. 7, n. 14, p. e141149-e141149, 2024.

MAO, Jun J. et al. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine, v. 22, n. 3, p. 394-399, 2015.

MCINTYRE, Roger S. et al. Head-to-head comparison of vortioxetine versus desvenlafaxine in patients with major depressive disorder with partial response to SSRI therapy: Results of the VIVRE study. The Journal of Clinical Psychiatry, v. 84, n. 4, p. 47173, 2023.

MUNARETTO, Giovanna Freitas et al. O IMPACTO SEXUAL DOS ANTIDEPRESSIVOS DUAIS E INIBIDORES DA RECAPTAÇÃO DE SEROTONINA EM MULHERES. Revista Contemporânea, v. 3, n. 11, p. 19875-19895, 2023.

PAVEI, Denise et al. A influência da dopamina nos transtornos de depressão: revisão de literatura. Arquivos de Ciências da Saúde da UNIPAR, v. 27, n. 8, p. 4153-4169, 2023.

PETERS, Evyn M. et al. Interpersonal sensitivity and response to selective serotonin reuptake inhibitors in patients with acute major depressive disorder. Journal of Affective Disorders, v. 355, p. 422-425, 2024.

POLAT, Emre Can et al. Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase‐5 inhibitors in the treatment of premature ejaculation. Andrologia, v. 47, n. 5, p. 487-492, 2015.

SHANG, Jing-Ye et al. A multiplex PCR for differential detection of Echinococcus granulosus sensu stricto, Echinococcus multilocularis and Echinococcus canadensis in China. Infectious diseases of poverty, v. 8, n. 04, p. 49-56, 2019.

SZMULEWICZ, Alejandro et al. Melancholic features and treatment outcome to selective serotonin reuptake inhibitors in major depressive disorder: A re-analysis of the STAR* D trial. Journal of Affective Disorders, v. 347, p. 101-107, 2024.

VALLE-CABRERA, Roselin et al. Efficacy of sertraline in patients with major depressive disorder naive to selective serotonin reuptake inhibitors: a 10-week randomized, Multicenter, Placebo-Controlled, Double-Blind, Academic Clinical Trial. Journal of clinical psychopharmacology, v. 38, n. 5, p. 454-459, 2018.

VASCONCELOS, José Lucas Moura et al. Antidepressivos na Ansiedade: Uma Abordagem Abrangente da Eficácia e Mecanismos de Ação. Brazilian Journal of Implantology and Health Sciences, v. 6, n. 1, p. 1716-1722, 2024.

WORLD HEALTH ORGANIZATION et al. Depression and other common mental disorders: global health estimates. World Health Organization, 2017.

Published

2026-01-04

Issue

Section

Articles

How to Cite

BATISTA, Guilherme Tadeu Souza; GAVILANES, Cinthya Millene do Nascimento; GAVILANES, Gabriel Alejandro do Nascimento; NUNES FILHO, Jonkelion Dourado; OLIVEIRA, Lívia Versiane. The use of selective serotonin reuptake inhibitors in the treatment of major depression: a bibliographical review. Journal of Social Issues and Health Sciences (JSIHS), [S. l.], v. 3, n. 1, 2026. DOI: 10.5281/zenodo.18143315. Disponível em: https://ojs.thesiseditora.com.br/index.php/jsihs/article/view/543.. Acesso em: 10 jan. 2026.