Analysis of morbidity and mortality due to endometriosis in Brazil: an ecological study from 2014 to 2024

Authors

DOI:

https://doi.org/10.5281/zenodo.15583765

Keywords:

Endometriosis, Public health, Hospital morbidity, Epidemiology, Economic burden

Abstract

Introduction: Endometriosis is a chronic disease affecting women of reproductive age, with significant clinical and economic impacts on the healthcare system. Objective: To analyze the profile of hospital morbidity and mortality due to endometriosis in Brazil from 2014 to 2024. Methodology: An ecological observational study using secondary data from the Hospital Information System (SIH/SUS) and Mortality Information System (SIM). Incidence, mortality rates, hospital stay duration, and healthcare costs were analyzed. Results: The national average hospitalization rate was 10.0 per 100,000 women, with higher incidence in the South and Southeast regions. Elective care predominated over emergency care (p < 0.0001). The average hospital stay was 16.45 days, with annual costs exceeding R$ 10 million and a significant increase in 2024. Correlation between hospitalizations and costs was weak and not significant. Conclusion: Endometriosis imposes a considerable burden on the healthcare system, highlighting the need for public policies to expand early diagnosis, professional training, and integrated care, especially in regions with limited diagnostic capacity. Limitations include the use of secondary data and lack of information on indirect costs and quality of life.

References

AOKI, T. et al. Endometriose: aspectos relevantes e atuais. Revista Brasileira de Ginecologia e Obstetrícia, São Paulo, v. 32, n. 6, p. 297–302, 2010. DOI: 10.1590/S0100-72032010000600008.

ARAÚJO, Francy Waltília Cruz; SCHMIDT, Debora Berger. O impacto da endometriose na qualidade de vida das mulheres. Brazilian Journal of Implantology and Health Sciences, v. 6, n. 8, p. 4714–4722, 2024. DOI: 10.36557/2674-8169.2024v6n8p4714-4722.

CALZADA, J. L. et al. Understanding Endometriosis: A Global and Inclusive Perspective on Women’s Health. Journal of Women’s Health and Research, v. 33, n. 1, p. 45–58, 2024.

CHEGINI, D. Proinflammatory and profibrotic mediators: principal effectors of adhesion formation and endometriosis progression. Reproductive Biology and Endocrinology, v. 1, art. 44, p. 1–8, 2002.

DA COSTA, H. D. et al. Endometriose no Brasil: perfil epidemiológico das internações nos últimos dez anos (2013–2022). Brazilian Journal of Health Review, v. 6, n. 3, p. 9484–9495, 2023. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59738/43181. Acesso em: 21 maio 2025.

ESHRE – European Society of Human Reproduction and Embryology. Diretrizes para o manejo da endometriose. Endometriosis Guideline – Management of Women with Endometriosis, 2022. Disponível em: https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Endometriosis-guideline.aspx. Acesso em: 21 maio 2025.

EYSTER, K. M. et al. The effect of endometriosis on the expression of genes in the eutopic endometrium: a microarray study. Fertility and Sterility, v. 88, supl. 3, p. 1500–1511, 2007.

FEBRASGO – Federação Brasileira das Associações de Ginecologia e Obstetrícia. Diretriz Nacional de Endometriose. São Paulo: FEBRASGO, 2021. Disponível em: https://www.febrasgo.org.br/pt/noticias/item/1264-diretriz-nacional-de-endometriose. Acesso em: 21 maio 2025.

LEONE ROBERTI MAGGIORE, U. et al. Epidemiology of infertility in women with endometriosis. Best Practice & Research Clinical Obstetrics & Gynaecology, v. 92, p. 102454, 2024. DOI: 10.1016/j.bpobgyn.2023.102454.

MEHEDINTU, C.; PLOTOGEA, M. N.; IONESCU, S.; ANTONOVICI, M. Endometriosis still a challenge. Journal of Medicine and Life, v. 7, n. 3, p. 349–357, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233437/.

OOSTERLYNCK, D. J. et al. Concentration of interleukin-1 in peritoneal fluid of women with endometriosis. Obstetrics & Gynecology, v. 77, n. 5, p. 767–770, 1991.

REIS, Nayra da Silva et al. Análise do perfil epidemiológico das internações por endometriose no Brasil: um estudo retrospectivo. Revista DELOS – Desarrollo Local Sostenible, Curitiba, v. 18, n. 67, p. 1–20, 2025. DOI: 10.55905/rdelosv18.n67-010.

WREN, B. G.; WU, B.; GUO, S. W. The expression of genes involved in inflammation, proliferation and tissue remodeling in endometriosis: a review. Gynecologic and Obstetric Investigation, v. 64, n. 1, p. 65–74, 2007.

Downloads

Published

2025-06-03

Issue

Section

Articles

How to Cite

SALVIANO, Francisco Wallace Bezerra; SALVIANO, Fátima Joyce Bezerra; VIEIRA, João Emanuel Braga Amaro; JOVINO, Thallyson Yuri Lira; ESMERALDO , Leonardo Feitosa; MONTENEGRO, Isabel Cristina Lacerda; LOPES E SILVA, Metton Ribeiro. Analysis of morbidity and mortality due to endometriosis in Brazil: an ecological study from 2014 to 2024. Journal of Social Issues and Health Sciences (JSIHS), [S. l.], v. 2, n. 5, 2025. DOI: 10.5281/zenodo.15583765. Disponível em: https://ojs.thesiseditora.com.br/index.php/jsihs/article/view/413.. Acesso em: 13 dec. 2025.